RCHY1

Gene Information

Official Symbol: RCHY1
Official Name: ring finger and CHY zinc finger domain containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 25898
UniProt: Q96PM5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13611
Expression level (log2 read counts): 4.78

Expression Distribution

Screen	Score
A-366 10μM R03 exp115	-1.88
R-DABN 8μM R03 exp111	-1.87
Isonicotinamide 500μM R03 exp129	-1.84
GSK461364A 0.1μM R03 exp126	-1.7

zf-CHY
zf-C3HC4

error-free translesion synthesis
translesion synthesis
DNA synthesis involved in DNA repair
postreplication repair
p53 binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
ubiquitin ligase complex
DNA biosynthetic process
positive regulation of protein ubiquitination
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein modification by small protein conjugation or removal
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
regulation of protein ubiquitination
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of protein modification by small protein conjugation or removal
ubiquitin-protein transferase activity
regulation of cellular protein catabolic process
signaling receptor binding
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
nuclear speck
positive regulation of catabolic process
DNA repair
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of proteolysis
DNA metabolic process
protein modification by small protein conjugation