RCOR1

Entrez Summary: N/A
UniProt Summary: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. {ECO:0000269|PubMed:11171972, ECO:0000269|PubMed:11516394, ECO:0000269|PubMed:12032298, ECO:0000269|PubMed:12399542, ECO:0000269|PubMed:12493763, ECO:0000269|PubMed:16079794, ECO:0000269|PubMed:16140033}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 27/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	9/28
bone	0/25
breast	3/33
central nervous system	0/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	2/75
lymphocyte	1/14
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	2/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ELM2
Myb DNA-binding

DNA repair complex
histone H4 deacetylation
histone deacetylation
protein deacetylation
transcriptional repressor complex
protein deacylation
macromolecule deacylation
transcription factor complex
transcription regulatory region DNA binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
blood coagulation
coagulation
hemostasis
transcription factor binding
histone modification
covalent chromatin modification
wound healing
regulation of body fluid levels
response to wounding
DNA-binding transcription factor activity
chromatin organization
viral process
symbiotic process
interspecies interaction between organisms
negative regulation of transcription by RNA polymerase II
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression