RDH8

Entrez Summary: This gene encodes a member of the short-chain dehydrogenase/reductase family. The encoded protein catalyzes the reduction of all-trans-retinal to all-trans-retinol, the first reaction step of the rhodopsin regeneration pathway. This enzymatic reaction is the rate-limiting step in the visual cycle. [provided by RefSeq, Feb 2014].
UniProt Summary: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

adh short
KR

NADP-retinol dehydrogenase activity
estradiol 17-beta-dehydrogenase activity
estrogen biosynthetic process
retinol dehydrogenase activity
estrogen metabolic process
retinol metabolic process
steroid hormone biosynthetic process
hormone biosynthetic process
primary alcohol metabolic process
retinoid metabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
steroid biosynthetic process
isoprenoid metabolic process
hormone metabolic process
visual perception
sensory perception of light stimulus
steroid metabolic process
alcohol metabolic process
organic hydroxy compound metabolic process
regulation of hormone levels
lipid biosynthetic process
cellular lipid metabolic process
oxidation-reduction process
sensory perception
lipid metabolic process
organic cyclic compound biosynthetic process
nervous system process
integral component of plasma membrane
small molecule metabolic process
system process