RGS10

Entrez Summary: N/A
UniProt Summary: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196). {ECO:0000269|PubMed:10608901, ECO:0000269|PubMed:11443111, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:8774883, ECO:0000269|PubMed:9353196}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

G protein-coupled acetylcholine receptor signaling pathway
G-protein alpha-subunit binding
acetylcholine receptor signaling pathway
response to amphetamine
cellular response to acetylcholine
response to acetylcholine
postsynaptic signal transduction
response to amine
response to bronchodilator
axon terminus
signal transduction involved in cellular response to ammonium ion
cellular response to ammonium ion
regulation of G protein-coupled receptor signaling pathway
dendritic spine
response to ammonium ion
GTPase activator activity
response to xenobiotic stimulus
GTPase activity
neuronal cell body
cellular response to drug
positive regulation of GTPase activity
synaptic signaling
regulation of GTPase activity
response to toxic substance
cellular response to hormone stimulus
cellular response to nitrogen compound
positive regulation of hydrolase activity
response to hormone
response to organonitrogen compound
response to drug
cellular response to oxygen-containing compound
response to nitrogen compound
cell-cell signaling
cellular response to endogenous stimulus
negative regulation of signal transduction
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
negative regulation of cell communication
negative regulation of signaling
positive regulation of catalytic activity