RGS14

Entrez Summary: N/A
UniProt Summary: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)- mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal- based learning and memory. {ECO:0000269|PubMed:15917656, ECO:0000269|PubMed:17635935}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

zygote asymmetric cell division
negative regulation of synaptic plasticity
GDP-dissociation inhibitor activity
asymmetric cell division
GTPase activating protein binding
receptor signaling complex adaptor activity
G-protein alpha-subunit binding
long-term memory
platelet-derived growth factor receptor signaling pathway
long-term synaptic potentiation
negative regulation of G protein-coupled receptor signaling pathway
visual learning
visual behavior
negative regulation of ERK1 and ERK2 cascade
negative regulation of MAP kinase activity
associative learning
PML body
memory
spindle
spindle pole
regulation of DNA-templated transcription in response to stress
negative regulation of protein serine/threonine kinase activity
regulation of G protein-coupled receptor signaling pathway
learning
dendritic spine
positive regulation of synaptic transmission
spindle organization
negative regulation of MAPK cascade
regulation of synaptic plasticity
postsynaptic membrane
negative regulation of protein kinase activity
microtubule binding
negative regulation of kinase activity
postsynaptic density
learning or memory
nucleocytoplasmic transport
nuclear transport
chromosome segregation
negative regulation of transferase activity
GTPase activator activity