RIC8B

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
QNZ 0.01μM R05 exp241	-1.88
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.77
Benzoate 20000μM R08 exp456	1.91
Dynasore 10μM R04 exp180	2

G-protein alpha-subunit binding
guanyl-nucleotide exchange factor activity
cell cortex
regulation of G protein-coupled receptor signaling pathway
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
centrosome
positive regulation of hydrolase activity
regulation of hydrolase activity
G protein-coupled receptor signaling pathway
positive regulation of catalytic activity
positive regulation of molecular function