RLF

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 20μM R00 exp26	-1.97
Tozasertib 0.1μM R07 exp414	-1.73
Sulforaphane 9μM R08 exp525	1.71
A-395N 10μM R05 exp219	1.74
Etoposide 0.1μM R05 exp198	1.9
Lead acetate 2000μM R08 exp498 no dilution day6	2.02

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone H3-K4 monomethylation
DNA integration
regulation of DNA methylation
histone H3-K4 methylation
histone lysine methylation
peptidyl-lysine methylation
histone methylation
protein alkylation
protein methylation
macromolecule methylation
methylation
peptidyl-lysine modification
regulation of DNA metabolic process
histone modification
covalent chromatin modification
chromatin organization
DNA metabolic process
zinc ion binding
peptidyl-amino acid modification
chromosome organization
positive regulation of transcription by RNA polymerase II
DNA binding
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process