RNF19B

Gene Information

Official Symbol: RNF19B
Official Name: ring finger protein 19B
Aliases and Previous Symbols: N/A
Entrez ID: 127544
UniProt: Q6ZMZ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 50ng/ml R00 exp36	-3.35
TRAIL 5ng/ml R00 exp35	-2.96
Aminopterin 0.005μM R07 exp335	-1.96
Pimelic-diphenylamide-106 5μM R00 exp28	1.7
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12670
Expression level (log2 read counts): 3.62

Expression Distribution

cytolytic granule
ubiquitin conjugating enzyme binding
protein autoubiquitination
ubiquitin binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
ubiquitin ligase complex
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
ubiquitin protein ligase activity
regulation of cellular protein catabolic process
protein polyubiquitination
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
adaptive immune response
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of proteolysis
protein modification by small protein conjugation
regulation of cellular catabolic process
cellular macromolecule catabolic process
endoplasmic reticulum membrane
protein modification by small protein conjugation or removal
regulation of catabolic process
endoplasmic reticulum
macromolecule catabolic process
organonitrogen compound catabolic process