RNF26

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379). {ECO:0000269|PubMed:25254379, ECO:0000269|PubMed:27368102}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nifuroxazide 1μM R01 exp51	-1.73
Pyridostatin 4μM R05 exp240	1.72

protein localization to perinuclear region of cytoplasm
negative regulation of defense response to virus
protein K11-linked ubiquitination
regulation of defense response to virus
endosome organization
negative regulation of response to biotic stimulus
negative regulation of immune effector process
regulation of type I interferon production
negative regulation of defense response
negative regulation of multi-organism process
ubiquitin protein ligase activity
protein polyubiquitination
vesicle organization
negative regulation of response to external stimulus
endomembrane system organization
negative regulation of immune system process
regulation of immune effector process
regulation of response to biotic stimulus
protein ubiquitination
regulation of cytokine production
regulation of defense response
protein modification by small protein conjugation
regulation of multi-organism process
zinc ion binding
endoplasmic reticulum membrane
protein modification by small protein conjugation or removal
regulation of response to external stimulus
regulation of response to stress
negative regulation of response to stimulus
regulation of immune system process