RPRD1A

Entrez Summary: N/A
UniProt Summary: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.06
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.93
Nicotinamide 2000μM R01 exp50	-1.87
Dinaciclib 0.007μM R07 exp355	-1.75
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.74
AICAR 240μM R03 exp116	1.72
GSK626616 14μM R08 exp485	1.74
A-395 10μM R05 exp218	1.87
Dimethyl-Sulfoxide 1pc R03 exp120	1.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dephosphorylation of RNA polymerase II C-terminal domain
RNA polymerase II, holoenzyme
RNA polymerase II complex binding
snRNA transcription by RNA polymerase II
snRNA transcription
mRNA 3-end processing
ncRNA transcription
RNA 3-end processing
protein dephosphorylation
dephosphorylation
mRNA processing
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression