RRM2B

Gene Information

Official Symbol: RRM2B
Official Name: ribonucleotide reductase regulatory TP53 inducible subunit M2B
Aliases and Previous Symbols: N/A
Entrez ID: 50484
UniProt: Q7LG56
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12137
Expression level (log2 read counts): 4.53

Expression Distribution

Screen	Score
Dorsomorphin 5μM R07 exp357	-2.46
Palbociclib 1μM R07 exp382	-2.03
Milciclib 2μM R08 exp502	-1.87

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
mitochondrial DNA replication
deoxyribonucleotide biosynthetic process
deoxyribonucleoside triphosphate metabolic process
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
nucleobase-containing small molecule interconversion
regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of signal transduction by p53 class mediator
deoxyribonucleotide metabolic process
response to amine
nucleoside triphosphate metabolic process
negative regulation of intrinsic apoptotic signaling pathway
renal system process
DNA-dependent DNA replication
regulation of intrinsic apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
DNA replication
negative regulation of apoptotic signaling pathway
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
kidney development
renal system development
urogenital system development
response to oxidative stress
regulation of apoptotic signaling pathway
nucleotide metabolic process
nucleoside phosphate metabolic process
negative regulation of intracellular signal transduction
DNA repair
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
DNA metabolic process
cellular response to DNA damage stimulus
organophosphate metabolic process
negative regulation of apoptotic process
negative regulation of programmed cell death
oxidation-reduction process
negative regulation of cell death
response to organonitrogen compound