RUSC1

Entrez Summary: N/A
UniProt Summary: Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. {ECO:0000269|PubMed:19365808}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.74
Latrunculin-B 10μM R07 exp374	1.75
VHL-ligand-1 20μM R07 exp421	1.78
UM131593 0.1μM R01 exp58	1.91
BI-2536 0.001μM R01 exp41	2.39
YM155 0.0002μM R01 exp61	2.41

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SH3/SH2 adaptor activity
microtubule cytoskeleton
postsynaptic membrane
postsynaptic density
cytoplasmic vesicle
early endosome
actin binding
protein polyubiquitination
microtubule
cell junction
protein ubiquitination
protein modification by small protein conjugation
Golgi apparatus
protein modification by small protein conjugation or removal
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling