SBF2

Entrez Summary: This gene encodes a pseudophosphatase and member of the myotubularin-related protein family. This gene maps within the CMT4B2 candidate region of chromosome 11p15 and mutations in this gene have been associated with Charcot-Marie-Tooth Disease, type 4B2. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UMK57 0.6μM R03 exp107	-1.79
Epothilone-B 0.0015μM R05 exp231	1.92

phosphatase regulator activity
vacuolar membrane
Rab guanyl-nucleotide exchange factor activity
phosphatase binding
phosphatidylinositol binding
myelination
ensheathment of neurons
axon ensheathment
protein tetramerization
endosome membrane
process utilizing autophagic mechanism
autophagy
axon
regulation of GTPase activity
protein complex oligomerization
perinuclear region of cytoplasm
regulation of hydrolase activity
protein-containing complex assembly
cellular catabolic process
protein-containing complex subunit organization
membrane