SCN4B

Entrez Summary: The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009].
UniProt Summary: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. {ECO:0000269|PubMed:24297919}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

voltage-gated sodium channel activity involved in cardiac muscle cell action potential
AV node cell to bundle of His cell signaling
AV node cell action potential
AV node cell to bundle of His cell communication
voltage-gated sodium channel complex
membrane depolarization during cardiac muscle cell action potential
voltage-gated sodium channel activity
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of cardiac muscle cell membrane repolarization
cell-cell signaling involved in cardiac conduction
membrane depolarization during action potential
regulation of membrane repolarization
sodium channel regulator activity
positive regulation of sodium ion transport
intrinsic component of plasma membrane
regulation of heart rate by cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
voltage-gated ion channel activity
cell communication involved in cardiac conduction
intercalated disc
cardiac muscle cell action potential
membrane depolarization
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
cardiac muscle contraction
heart contraction
regulation of sodium ion transport
actin-mediated cell contraction
sodium ion transmembrane transport
cardiac conduction
action potential
regulation of heart rate
heart process
striated muscle contraction
actin filament-based movement
ion channel binding
multicellular organismal signaling
sodium ion transport
regulation of heart contraction