SCT
Gene Information
- Official Symbol: SCT
- Official Name: secretin
- Aliases and Previous Symbols: N/A
- Entrez ID: 6343
- UniProt: P09683
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.
Pfam Domains GO Terms
Pfam Domains
| Hormone 2 |
GO Terms
| positive regulation of pancreatic juice secretion |
| negative regulation of gastrin-induced gastric acid secretion |
| regulation of gastrin-induced gastric acid secretion |
| digestive hormone activity |
| positive regulation of somatostatin secretion |
| regulation of somatostatin secretion |
| cellular water homeostasis |
| regulation of pancreatic juice secretion |
| pancreatic juice secretion |
| negative regulation of gastric acid secretion |
| positive regulation of digestive system process |
| regulation of gastric acid secretion |
| diet induced thermogenesis |
| negative regulation of digestive system process |
| adaptive thermogenesis |
| secretion by tissue |
| positive regulation of cAMP-mediated signaling |
| regulation of appetite |
| positive regulation of lipid catabolic process |
| response to dietary excess |
| cell volume homeostasis |
| embryonic digestive tract development |
| regulation of digestive system process |
| regulation of cAMP-mediated signaling |
| regulation of lipid catabolic process |
| G protein-coupled receptor binding |
| water homeostasis |
| digestive system process |
| body fluid secretion |
| cell |
| hippocampus development |
| positive regulation of peptide hormone secretion |
| hormone activity |
| protein N-terminus binding |
| limbic system development |
| digestion |
| positive regulation of hormone secretion |
| digestive tract development |
| positive regulation of lipid metabolic process |
| digestive system development |
| pallium development |
| regulation of cell size |
| regulation of synaptic plasticity |
| regulation of peptide hormone secretion |
| negative regulation of secretion |
| telencephalon development |
| regulation of hormone secretion |
| positive regulation of peptide secretion |
| signaling receptor binding |
| regulation of cellular component size |
| forebrain development |
| regulation of lipid metabolic process |
| positive regulation of secretion by cell |
| positive regulation of catabolic process |
| embryonic organ development |
| positive regulation of secretion |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| cellular component |
| negative regulation of transport |
| regulation of peptide secretion |
| regulation of body fluid levels |
| response to nutrient levels |
| regulation of anatomical structure size |
| response to extracellular stimulus |
| regulation of hormone levels |
| regulation of system process |
| regulation of peptide transport |
| brain development |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| head development |
| regulation of secretion |
| tube development |
| cellular homeostasis |
| embryo development |
| central nervous system development |
| positive regulation of transport |
| regulation of catabolic process |
| positive regulation of intracellular signal transduction |
| chemical homeostasis |
| secretion |
| negative regulation of multicellular organismal process |
| G protein-coupled receptor signaling pathway |
| extracellular space |
| homeostatic process |
| positive regulation of signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pterostilbene 16μM R02 exp78 | -1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7977
- Expression level (log2 read counts): -2.9
Expression Distribution
SCT Expression in NALM6 Cells: -2.9
