SEC23A

Entrez Summary: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008].
UniProt Summary: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. {ECO:0000269|PubMed:16980979, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:27551091, ECO:0000269|PubMed:8898360}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Hinokiflavone 12μM R08 exp487	-2.38
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.7

COPII-coated vesicle cargo loading
COPII vesicle coat
vesicle cargo loading
endoplasmic reticulum exit site
ER to Golgi transport vesicle membrane
vesicle targeting, rough ER to cis-Golgi
COPII vesicle coating
extrinsic component of membrane
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
localization within membrane
vesicle targeting
vesicle budding from membrane
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
establishment of vesicle localization
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
protein localization to plasma membrane
vesicle localization
antigen processing and presentation of peptide antigen
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
protein localization to cell periphery
GTPase activator activity
vesicle organization
establishment of organelle localization
Golgi vesicle transport
positive regulation of GTPase activity
protein localization to membrane
regulation of GTPase activity
organelle localization
Golgi membrane
perinuclear region of cytoplasm
positive regulation of hydrolase activity
zinc ion binding