SEMG2

Entrez Summary: N/A
UniProt Summary: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PU-H71 1μM R08 exp515	-1.7
Phenformin 20μM R05 exp212	1.7
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.88
THZ531 0.11μM R07 exp409	2.27

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of serine-type peptidase activity
positive regulation of serine-type endopeptidase activity
negative regulation of cilium-dependent cell motility
negative regulation of flagellated sperm motility
regulation of serine-type peptidase activity
regulation of serine-type endopeptidase activity
regulation of flagellated sperm motility
regulation of cilium-dependent cell motility
sperm capacitation
antibacterial humoral response
negative regulation of reproductive process
protease binding
protein heterooligomerization
antimicrobial humoral response
spermatid development
spermatid differentiation
cell maturation
regulation of reproductive process
positive regulation of endopeptidase activity
positive regulation of peptidase activity
developmental maturation
germ cell development
negative regulation of cell motility
coagulation
negative regulation of cellular component movement
negative regulation of locomotion
defense response to bacterium
humoral immune response
cellular process involved in reproduction in multicellular organism
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
protein complex oligomerization
spermatogenesis
male gamete generation
developmental process involved in reproduction
response to bacterium
gamete generation
regulation of proteolysis
positive regulation of hydrolase activity