SERINC1

Entrez Summary: N/A
UniProt Summary: Enhances the incorporation of serine into phosphatidylserine and sphingolipids. {ECO:0000250|UniProtKB:Q7TNK0}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM131593 0.1μM R01 exp58	1.7
FK-506 30μM R07 exp359	1.89

positive regulation of serine C-palmitoyltransferase activity
positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
regulation of serine C-palmitoyltransferase activity
phosphatidylserine metabolic process
membrane biogenesis
protein binding, bridging
sphingolipid metabolic process
cellular modified amino acid metabolic process
membrane lipid metabolic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
enzyme binding
phospholipid metabolic process
glycerolipid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
positive regulation of transferase activity
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
regulation of transferase activity
lipid metabolic process
positive regulation of catalytic activity
positive regulation of molecular function