SH3RF2

Gene Information

Official Symbol: SH3RF2
Official Name: SH3 domain containing ring finger 2
Aliases and Previous Symbols: N/A
Entrez ID: 153769
UniProt: Q8TEC5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function. {ECO:0000269|PubMed:19389623, ECO:0000269|PubMed:19945436, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13678
Expression level (log2 read counts): 0.65

Expression Distribution

Screen	Score
R-DABN 8μM R03 exp111	-1.92
Q15 1 to 2μM on day4 R04 exp164	-1.77
Vinblastine 0.015μM R05 exp208	-1.73

SH3 1
SH3 2
zf-C3HC4

protein phosphatase 1 binding
protein phosphatase inhibitor activity
negative regulation of JNK cascade
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of stress-activated MAPK cascade
phosphatase binding
negative regulation of phosphoprotein phosphatase activity
protein autoubiquitination
negative regulation of protein dephosphorylation
negative regulation of protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of protein modification by small protein conjugation or removal
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of JNK cascade
regulation of protein dephosphorylation
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
positive regulation of stress-activated MAPK cascade
negative regulation of MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of phosphatase activity
regulation of proteasomal protein catabolic process
regulation of JNK cascade
regulation of protein ubiquitination
regulation of dephosphorylation
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
ubiquitin protein ligase activity
regulation of protein modification by small protein conjugation or removal
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of cellular protein catabolic process
positive regulation of proteolysis
positive regulation of cellular catabolic process