SLC13A5

Gene Information
  • Official Symbol: SLC13A5
  • Official Name: solute carrier family 13 member 5
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 284111
  • UniProt: Q86YT5
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
  • UniProt Summary: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. {ECO:0000269|PubMed:12445824, ECO:0000269|PubMed:26384929}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 3369
  • Expression level (log2 read counts): 2.93

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1