SLC17A8

Entrez Summary: This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
UniProt Summary: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:12151341}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pericellular basket
glial limiting end-foot
basal dendrite
neurotransmitter transmembrane transporter activity
neurotransmitter loading into synaptic vesicle
L-glutamate transmembrane transporter activity
apical dendrite
L-glutamate transmembrane transport
synaptic transmission, glutamatergic
excitatory synapse
multivesicular body
integral component of synaptic vesicle membrane
symporter activity
L-alpha-amino acid transmembrane transport
acidic amino acid transport
cochlea development
axon terminus
neural retina development
L-amino acid transport
synaptic vesicle membrane
drug transmembrane transport
amino acid transmembrane transport
dicarboxylic acid transport
amino acid transport
synaptic vesicle cycle
carboxylic acid transmembrane transport
organic acid transmembrane transport
vesicle-mediated transport in synapse
perikaryon
retina development in camera-type eye
sensory perception of sound
drug transport
sodium ion transport
sensory perception of mechanical stimulus
neurotransmitter transport
inner ear development
ear development
regulation of synapse structure or activity
anion transmembrane transport
organic acid transport