SLC25A12

Gene Information

Official Symbol: SLC25A12
Official Name: solute carrier family 25 member 12
Aliases and Previous Symbols: N/A
Entrez ID: 8604
UniProt: O75746
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012].
UniProt Summary: Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. {ECO:0000269|PubMed:11566871}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5964
Expression level (log2 read counts): 5.54

Expression Distribution

Screen	Score
Nifuroxazide 5μM R03 exp102	-2.09
BI-2536 0.02μM R03 exp96	1.76

negative regulation of glucose catabolic process to lactate via pyruvate
negative regulation of NAD metabolic process
regulation of NAD metabolic process
negative regulation of fermentation
regulation of glucose catabolic process to lactate via pyruvate
malate-aspartate shuttle
regulation of fermentation
L-aspartate transmembrane transporter activity
glutamate biosynthetic process
L-aspartate transmembrane transport
aspartate transmembrane transport
L-glutamate transmembrane transporter activity
positive regulation of ATP biosynthetic process
dicarboxylic acid biosynthetic process
positive regulation of myelination
regulation of ATP biosynthetic process
L-glutamate transmembrane transport
glutamine family amino acid biosynthetic process
positive regulation of purine nucleotide biosynthetic process
positive regulation of nucleotide biosynthetic process
C4-dicarboxylate transport
negative regulation of ATP metabolic process
glutamate metabolic process
positive regulation of glucose metabolic process
regulation of purine nucleotide biosynthetic process
regulation of nucleotide biosynthetic process
regulation of myelination
gluconeogenesis
positive regulation of purine nucleotide metabolic process
positive regulation of ATP metabolic process
positive regulation of nucleotide metabolic process
L-alpha-amino acid transmembrane transport
acidic amino acid transport
hexose biosynthetic process
negative regulation of carbohydrate metabolic process
monosaccharide biosynthetic process
positive regulation of cellular carbohydrate metabolic process
L-amino acid transport
positive regulation of nervous system process
alpha-amino acid biosynthetic process