SLC25A38

Entrez Summary: This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia (anemia, sideroblastic, 2, pyridoxine-refractory). A related pseudogene is found on chromosome 1. [provided by RefSeq, Aug 2017].
UniProt Summary: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. {ECO:0000255|HAMAP-Rule:MF_03064, ECO:0000269|PubMed:19412178, ECO:0000269|PubMed:27476175}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glycine import into mitochondrion
glycine transmembrane transporter activity
glycine transport
amino acid import
heme biosynthetic process
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
heme metabolic process
neutral amino acid transport
porphyrin-containing compound metabolic process
L-alpha-amino acid transmembrane transport
pigment biosynthetic process
L-amino acid transport
tetrapyrrole metabolic process
pigment metabolic process
drug transmembrane transport
amino acid transmembrane transport
erythrocyte differentiation
erythrocyte homeostasis
mitochondrial transmembrane transport
myeloid cell homeostasis
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
drug transport
neurotransmitter transport
homeostasis of number of cells
cofactor biosynthetic process
mitochondrial transport
myeloid cell differentiation
anion transmembrane transport
organic acid transport
carboxylic acid transport
mitochondrial inner membrane
cofactor metabolic process
organic anion transport
hemopoiesis
anion transport
hematopoietic or lymphoid organ development
cation transmembrane transport