SLC35D2

Entrez Summary: N/A
UniProt Summary: Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Adefovir 20μM R07 exp332	1.73
IU1-C 25μM R04 exp183	1.86

UDP-N-acetylgalactosamine transmembrane transporter activity
UDP-glucuronic acid transmembrane transporter activity
UDP-glucuronic acid transmembrane transport
UDP-N-acetylgalactosamine transmembrane transport
nucleotide-sugar transmembrane transporter activity
UDP-N-acetylglucosamine transmembrane transport
UDP-N-acetylglucosamine transmembrane transporter activity
pyrimidine nucleotide-sugar transmembrane transporter activity
pyrimidine nucleotide-sugar transmembrane transport
nucleotide-sugar transmembrane transport
antiporter activity
keratan sulfate biosynthetic process
keratan sulfate metabolic process
transmembrane transporter activity
carbohydrate derivative transport
carbohydrate transport
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
organic acid transmembrane transport
carboxylic acid transmembrane transport
glycosaminoglycan metabolic process
aminoglycan metabolic process
sulfur compound biosynthetic process
nucleobase-containing compound transport
anion transmembrane transport
carboxylic acid transport
organic acid transport
sulfur compound metabolic process
organic anion transport
anion transport
carbohydrate derivative biosynthetic process
Golgi membrane
ion transmembrane transport
Golgi apparatus
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
transmembrane transport
ion transport