SLC9A2

Entrez Summary: This gene encodes a member of the sodium-hydrogen exchanger (NHE) protein family. These proteins are involved in sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and help in the regulation of cell pH and volume. The encoded protein is localized to the apical membrane and is involved in apical absorption of sodium. [provided by RefSeq, Jun 2016].
UniProt Summary: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

potassium:proton antiporter activity
sodium:proton antiporter activity
sodium ion import across plasma membrane
inorganic cation import across plasma membrane
inorganic ion import across plasma membrane
regulation of intracellular pH
sodium ion transmembrane transport
regulation of cellular pH
import across plasma membrane
regulation of pH
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
proton transmembrane transport
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
anion transmembrane transport
monovalent inorganic cation transport
inorganic cation transmembrane transport
anion transport
cation transmembrane transport
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
import into cell
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cation transport
cellular homeostasis
ion transmembrane transport
chemical homeostasis
transmembrane transport
ion transport
homeostatic process