SLCO2B1

Entrez Summary: This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010].
UniProt Summary: Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Sulforaphane 9μM R08 exp525	-1.72
Doxorubicin 0.02μM R08 exp478	1.72
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.93

OATP
MFS 1

organic anion transmembrane transporter activity
bile acid transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
sodium-independent organic anion transport
bile acid and bile salt transport
monocarboxylic acid transport
organic hydroxy compound transport
organic acid transport
carboxylic acid transport
lipid transport
lipid localization
organic anion transport
anion transport
transmembrane transport
ion transport
integral component of plasma membrane