SNRNP40

Entrez Summary: N/A
UniProt Summary: Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. {ECO:0000269|PubMed:9774689}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 265/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	12/28
blood	11/28
bone	7/26
breast	16/33
central nervous system	13/56
cervix	1/4
colorectal	9/17
esophagus	7/13
fibroblast	0/1
gastric	5/16
kidney	5/21
liver	5/20
lung	27/75
lymphocyte	5/16
ovary	12/26
pancreas	10/24
peripheral nervous system	7/16
plasma cell	8/15
prostate	0/1
skin	9/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	12/22
urinary tract	14/29
uterus	2/5

Expression Distribution

small nucleolar ribonucleoprotein complex
U5 snRNP
U2-type catalytic step 2 spliceosome
catalytic step 2 spliceosome
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
RNA binding
RNA metabolic process
gene expression