SNRPB2

Entrez Summary: N/A
UniProt Summary: Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A' protein.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 128/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	12/28
blood	2/28
bone	4/26
breast	13/33
central nervous system	15/56
cervix	0/4
colorectal	4/17
esophagus	4/13
fibroblast	0/1
gastric	1/16
kidney	6/21
liver	3/20
lung	10/75
lymphocyte	3/16
ovary	4/26
pancreas	6/24
peripheral nervous system	1/16
plasma cell	3/15
prostate	0/1
skin	2/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	7/29
uterus	0/5

Expression Distribution

snRNP binding
U1 snRNA binding
U1 snRNP
U2 snRNP
U2-type catalytic step 2 spliceosome
U2-type precatalytic spliceosome
catalytic step 2 spliceosome
spliceosomal complex
fibrillar center
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
RNA metabolic process
gene expression