SPINT1

Entrez Summary: The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-2.01
CFI-400945 25μM R08 exp469	1.98

branching involved in labyrinthine layer morphogenesis
labyrinthine layer morphogenesis
negative regulation of neural precursor cell proliferation
embryonic placenta morphogenesis
placenta blood vessel development
positive regulation of glial cell differentiation
labyrinthine layer development
positive regulation of gliogenesis
regulation of glial cell differentiation
embryonic placenta development
regulation of neural precursor cell proliferation
neural tube closure
tube closure
serine-type endopeptidase inhibitor activity
primary neural tube formation
cellular response to BMP stimulus
response to BMP
neural tube formation
regulation of gliogenesis
embryonic epithelial tube formation
epithelial tube formation
morphogenesis of embryonic epithelium
tube formation
placenta development
morphogenesis of a branching epithelium
neural tube development
morphogenesis of a branching structure
negative regulation of endopeptidase activity
negative regulation of peptidase activity
epithelial tube morphogenesis
extracellular matrix organization
negative regulation of proteolysis
in utero embryonic development
extracellular structure organization
regulation of endopeptidase activity
reproductive structure development
reproductive system development
morphogenesis of an epithelium
embryonic organ development
regulation of peptidase activity