SRR

Entrez Summary: N/A
UniProt Summary: Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. {ECO:0000269|PubMed:11054547, ECO:0000269|PubMed:20106978}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

serine racemase activity
D-amino acid biosynthetic process
threonine racemase activity
D-serine biosynthetic process
D-serine ammonia-lyase activity
D-serine metabolic process
L-serine ammonia-lyase activity
D-amino acid metabolic process
pyruvate biosynthetic process
L-serine biosynthetic process
L-serine metabolic process
glycine binding
serine family amino acid biosynthetic process
response to morphine
response to isoquinoline alkaloid
serine family amino acid metabolic process
pyridoxal phosphate binding
alpha-amino acid biosynthetic process
pyruvate metabolic process
apical part of cell
response to anesthetic
cellular amino acid biosynthetic process
PDZ domain binding
protein homotetramerization
response to alkaloid
protein tetramerization
response to ammonium ion
monocarboxylic acid biosynthetic process
alpha-amino acid metabolic process
magnesium ion binding
aging
response to xenobiotic stimulus
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
response to lipopolysaccharide
response to molecule of bacterial origin
protein homooligomerization
neuronal cell body
drug metabolic process