SSR1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.19
Dimethyloxaloylglycine 100μM R05 exp229	-1.93
Lenalidomide 20μM R07 exp375	-1.81
Lead acetate 2000μM R08 exp497	-1.73
Rapamycin 0.001μM R08 exp429	1.72
Phenformin 20μM R03 exp143	1.9
Tunicamycin 0.04μM R07 exp418	1.94
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.99
Trimetrexate 0.03μM R08 exp535	2.91

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
SSR2	0.476
SSR3	0.461

IRE1-mediated unfolded protein response
cotranslational protein targeting to membrane
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
cellular response to topologically incorrect protein
protein targeting to membrane
response to unfolded protein
response to topologically incorrect protein
response to endoplasmic reticulum stress
establishment of protein localization to membrane
protein targeting
protein localization to membrane
positive regulation of cell population proliferation
endoplasmic reticulum membrane
intracellular protein transport
endoplasmic reticulum
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
regulation of cell population proliferation
cellular response to stress
establishment of localization in cell
nitrogen compound transport