SSTR5

Entrez Summary: Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010].
UniProt Summary: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. {ECO:0000269|PubMed:12072395, ECO:0000269|PubMed:7908405, ECO:0000269|PubMed:8078491, ECO:0000269|PubMed:8373420}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7tm 1
7TM GPCR Srsx

somatostatin receptor signaling pathway
somatostatin signaling pathway
somatostatin receptor activity
neuropeptide binding
positive regulation of cytokinesis
peptide binding
cellular response to glucocorticoid stimulus
cellular response to corticosteroid stimulus
positive regulation of cell division
regulation of cytokinesis
neuropeptide signaling pathway
response to glucocorticoid
response to corticosteroid
regulation of cell division
hormone-mediated signaling pathway
regulation of insulin secretion
glucose homeostasis
carbohydrate homeostasis
cellular response to steroid hormone stimulus
regulation of peptide hormone secretion
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of hormone secretion
positive regulation of cell cycle process
response to steroid hormone
positive regulation of cell cycle
regulation of protein secretion
regulation of peptide secretion
cellular response to lipid
regulation of hormone levels
cellular response to organic cyclic compound
cellular response to hormone stimulus
negative regulation of cell population proliferation
regulation of protein transport
G protein-coupled receptor activity
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of cell cycle process
regulation of secretion
response to lipid