ST8SIA1

Entrez Summary: N/A
UniProt Summary: Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. {ECO:0000269|PubMed:7937974, ECO:0000269|PubMed:8058740, ECO:0000269|PubMed:8195250, ECO:0000269|PubMed:8631981}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Deguelin 0.15μM R05 exp209	1.7
WNT3A 44ng/ml R08 exp537	2

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
sialyltransferase activity
sialylation
glycosphingolipid biosynthetic process
glycolipid biosynthetic process
glycosphingolipid metabolic process
cellular response to heat
sphingolipid biosynthetic process
glycolipid metabolic process
response to heat
liposaccharide metabolic process
membrane lipid biosynthetic process
sphingolipid metabolic process
response to temperature stimulus
membrane lipid metabolic process
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
Golgi membrane
positive regulation of cell population proliferation
cellular lipid metabolic process
carbohydrate derivative metabolic process
response to abiotic stimulus
lipid metabolic process
organonitrogen compound biosynthetic process
regulation of cell population proliferation
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process