ST8SIA6

Entrez Summary: This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
UniProt Summary: Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc- alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
DKK1 89ng/ml R08 exp477	-2.38
Dinaciclib 0.007μM R07 exp355	-1.87

ganglioside biosynthetic process
sialyltransferase activity
ganglioside metabolic process
sialylation
glycosphingolipid biosynthetic process
hatching
organism emergence from protective structure
blastocyst hatching
ceramide biosynthetic process
oligosaccharide metabolic process
glycolipid biosynthetic process
glycosphingolipid metabolic process
ceramide metabolic process
sphingolipid biosynthetic process
blastocyst development
glycolipid metabolic process
liposaccharide metabolic process
protein O-linked glycosylation
carbohydrate biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
in utero embryonic development
glycoprotein metabolic process
carbohydrate metabolic process
amide biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
Golgi membrane
chordate embryonic development
embryo development ending in birth or egg hatching
cellular amide metabolic process
cellular lipid metabolic process
embryo development
carbohydrate derivative metabolic process
lipid metabolic process