STAG3
Gene Information
- Official Symbol: STAG3
- Official Name: stromal antigen 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 10734
- UniProt: Q9UJ98
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014].
- UniProt Summary: Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis- specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. {ECO:0000250|UniProtKB:O70576}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4073
- Expression level (log2 read counts): 5.92
STAG3 Expression in NALM6 Cells: 5.92
