STRA8

Entrez Summary: N/A
UniProt Summary: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription (By similarity). {ECO:0000250|UniProtKB:P70278}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

male germ-line stem cell asymmetric division
germline stem cell asymmetric division
germ-line stem cell division
asymmetric stem cell division
asymmetric cell division
stem cell division
cellular response to retinoic acid
oogenesis
response to retinoic acid
female gamete generation
protein dimerization activity
cellular response to acid chemical
DNA replication
meiotic cell cycle
germ cell development
response to acid chemical
cellular process involved in reproduction in multicellular organism
cell division
cellular response to lipid
spermatogenesis
male gamete generation
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
response to lipid
multi-organism reproductive process
cellular response to oxygen-containing compound
positive regulation of transcription by RNA polymerase II
cell cycle
reproductive process
reproduction
positive regulation of transcription, DNA-templated
response to oxygen-containing compound
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
cell development
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process