STXBP5

Entrez Summary: N/A
UniProt Summary: Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

extrinsic component of presynaptic membrane
myosin II binding
presynaptic cytosol
acetylcholine-gated channel complex
syntaxin-1 binding
SNARE complex
syntaxin binding
neuromuscular junction
Schaffer collateral - CA1 synapse
positive regulation of exocytosis
synaptic vesicle cycle
synaptic vesicle
vesicle-mediated transport in synapse
cytoplasmic vesicle membrane
Rab GTPase binding
regulation of exocytosis
GTPase activator activity
positive regulation of secretion by cell
positive regulation of GTPase activity
positive regulation of secretion
regulation of GTPase activity
cell junction
regulation of vesicle-mediated transport
regulation of secretion by cell
positive regulation of hydrolase activity
exocytosis
regulation of secretion
positive regulation of transport
secretion by cell
export from cell
secretion
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
peptide transport
amide transport
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport