SV2A

Entrez Summary: The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. [provided by RefSeq, Jun 2016].
UniProt Summary: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
6-Thio-2-deoxyguanosine 2μM R06 exp259	-2.27
Pimelic-diphenylamide-106 5μM R00 exp28	-1.93
ML-792 0.2μM R08 exp505	-1.74
Dimethyloxaloylglycine 100μM R05 exp229	-1.73
Nocodazole 0.2μM R02 exp64	1.7
Docosahexaenoic-acid 50μM R07 exp356	1.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sugar tr
MFS 1

regulation of gamma-aminobutyric acid secretion
synaptic vesicle priming
regulation of amino acid transport
integral component of synaptic vesicle membrane
presynaptic active zone
regulation of organic acid transport
transmembrane transporter activity
synaptic vesicle exocytosis
GABA-ergic synapse
exocytic process
synaptic vesicle membrane
neuromuscular junction
regulation of amine transport
regulation of anion transport
neurotransmitter secretion
signal release from synapse
synaptic vesicle cycle
synaptic vesicle
vesicle-mediated transport in synapse
regulation of neurotransmitter transport
signal release
cell-cell junction
neurotransmitter transport
neuron projection
glutamatergic synapse
regulation of neurotransmitter levels
neuronal cell body
dendrite
chemical synaptic transmission
anterograde trans-synaptic signaling
cellular calcium ion homeostasis
trans-synaptic signaling
calcium ion homeostasis
synaptic signaling
protein kinase binding
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis