SYP

Entrez Summary: This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017].
UniProt Summary: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
5-Fluorouracil 20μM R00 exp2	-1.86
Nicotinamide 1000μM R03 exp101	-1.7

regulation of opioid receptor signaling pathway
synaptic vesicle membrane organization
synaptic vesicle maturation
regulation of short-term neuronal synaptic plasticity
syntaxin-1 binding
regulation of long-term neuronal synaptic plasticity
excitatory synapse
integral component of synaptic vesicle membrane
presynaptic active zone
SH2 domain binding
presynaptic endocytosis
synaptic vesicle endocytosis
cholesterol binding
terminal bouton
synaptic vesicle recycling
regulation of neuronal synaptic plasticity
protein self-association
synaptic vesicle membrane
presynaptic membrane
neuromuscular junction
regulation of synaptic vesicle exocytosis
Schaffer collateral - CA1 synapse
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
synaptic vesicle cycle
synaptic vesicle
vesicle-mediated transport in synapse
regulation of neurotransmitter transport
regulation of G protein-coupled receptor signaling pathway
regulation of regulated secretory pathway
regulation of synaptic plasticity
regulation of exocytosis
developmental maturation
vesicle organization
neuron projection
regulation of neurotransmitter levels
endomembrane system organization
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
cell junction