TAF9B

Gene Information

Official Symbol: TAF9B
Official Name: TATA-box binding protein associated factor 9b
Aliases and Previous Symbols: N/A
Entrez ID: 51616
UniProt: Q9HBM6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008].
UniProt Summary: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. {ECO:0000269|PubMed:15899866}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9659
Expression level (log2 read counts): 4.59

Expression Distribution

Screen	Score
Cytochalasin-B 5μM R07 exp349	-1.78
IU1-47 25μM R04 exp182	-1.71

transcription factor TFTC complex
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
SAGA complex
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of signal transduction by p53 class mediator
transcription factor TFIID complex
regulation of intrinsic apoptotic signaling pathway in response to DNA damage
histone H3 acetylation
histone acetyltransferase activity
negative regulation of response to DNA damage stimulus
negative regulation of intrinsic apoptotic signaling pathway
histone acetylation
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
protein acetylation
regulation of intrinsic apoptotic signaling pathway
positive regulation of cell growth
transcription initiation from RNA polymerase II promoter
protein stabilization
regulation of signal transduction by p53 class mediator
protein acylation
DNA-templated transcription, initiation
regulation of response to DNA damage stimulus
transcription regulatory region DNA binding
negative regulation of apoptotic signaling pathway
transcription corepressor activity
positive regulation of growth
protein deubiquitination
regulation of protein stability
protein modification by small protein removal
peptidyl-lysine modification
transcription factor binding
histone modification
covalent chromatin modification
regulation of apoptotic signaling pathway
regulation of cell growth