TAOK3

Gene Information

Official Symbol: TAOK3
Official Name: TAO kinase 3
Aliases and Previous Symbols: N/A
Entrez ID: 51347
UniProt: Q9H2K8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016].
UniProt Summary: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). {ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.27
Bortezomib 0.005μM R00 exp6	-2.22
Nocodazole 0.2μM R00 exp24	-1.98
Lead acetate 2000μM R08 exp498 no dilution day6	-1.89
Docetaxel 0.002μM R01 exp45	-1.74
Azithromycin 100μM R08 exp452	1.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15415
Expression level (log2 read counts): 6.51

Expression Distribution

Pkinase Tyr
Pkinase

mitotic G2 DNA damage checkpoint
MAP kinase kinase kinase activity
mitotic G2/M transition checkpoint
protein kinase inhibitor activity
G2 DNA damage checkpoint
negative regulation of JNK cascade
negative regulation of stress-activated MAPK cascade
negative regulation of stress-activated protein kinase signaling cascade
activation of MAPKK activity
transferase activity
positive regulation of JUN kinase activity
regulation of JUN kinase activity
negative regulation of G2/M transition of mitotic cell cycle
mitotic DNA damage checkpoint
negative regulation of cell cycle G2/M phase transition
mitotic DNA integrity checkpoint
DNA damage checkpoint
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
DNA integrity checkpoint
mitotic cell cycle checkpoint
negative regulation of MAPK cascade
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
cell cycle checkpoint
protein autophosphorylation
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
negative regulation of protein kinase activity
negative regulation of cell cycle phase transition
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
negative regulation of kinase activity
positive regulation of MAP kinase activity
negative regulation of transferase activity
negative regulation of mitotic cell cycle
negative regulation of cell cycle process
activation of protein kinase activity