TAT

Entrez Summary: This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible cognitive disability. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008].
UniProt Summary: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. {ECO:0000269|PubMed:16640556, ECO:0000269|PubMed:7999802}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LJH685 5μM R02 exp73	1.7
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.72
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.77
Celastrol 0.12μM R05 exp225	2.22

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

L-tyrosine:2-oxoglutarate aminotransferase activity
tyrosine catabolic process
tyrosine metabolic process
response to mercury ion
L-phenylalanine catabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
L-phenylalanine metabolic process
erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process
2-oxoglutarate metabolic process
amino acid binding
aromatic amino acid family catabolic process
glutamate metabolic process
aromatic amino acid family metabolic process
pyridoxal phosphate binding
glutamine family amino acid metabolic process
dicarboxylic acid metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
response to glucocorticoid
drug catabolic process
response to corticosteroid
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
cellular amino acid metabolic process
response to steroid hormone
response to metal ion
response to oxidative stress
small molecule catabolic process
cofactor metabolic process
aromatic compound catabolic process
cellular component
organic cyclic compound catabolic process
drug metabolic process
response to inorganic substance
response to lipid
carboxylic acid metabolic process
response to hormone
response to organic cyclic compound
oxoacid metabolic process