TBC1D17

Gene Information
  • Official Symbol: TBC1D17
  • Official Name: TBC1 domain family member 17
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 79735
  • UniProt: Q9HA65
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known. {ECO:0000269|PubMed:22854040, ECO:0000269|PubMed:24752605}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 10964
  • Expression level (log2 read counts): 4.28

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1