TBR1

Entrez Summary: This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015].
UniProt Summary: Probable transcriptional regulator involved in developmental processes. Required for normal brain development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

amygdala development
conditioned taste aversion
commitment of neuronal cell to specific neuron type in forebrain
forebrain neuron fate commitment
specification of animal organ identity
animal organ formation
regulation of axon guidance
forebrain neuron differentiation
RNA polymerase II activating transcription factor binding
neuron fate commitment
forebrain generation of neurons
associative learning
feeding behavior
cell fate specification
limbic system development
cerebral cortex development
learning
hindbrain development
pallium development
central nervous system neuron differentiation
regulation of axonogenesis
regulation of chemotaxis
cell fate commitment
telencephalon development
learning or memory
cognition
regulation of cell morphogenesis involved in differentiation
RNA polymerase II regulatory region sequence-specific DNA binding
regionalization
forebrain development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
protein kinase binding
regulation of cell morphogenesis
regulation of neuron projection development
RNA polymerase II proximal promoter sequence-specific DNA binding
behavior
regulation of neuron differentiation
DNA-binding transcription factor activity
regulation of plasma membrane bounded cell projection organization