TEAD2

Entrez Summary: N/A
UniProt Summary: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'- GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Actinomycin-D 0.01μM R00 exp4	-1.92
Trichostatin-A 0.06μM R07 exp415	-1.85

TEAD-2-YAP complex
transcription regulator recruiting activity
lateral mesoderm development
paraxial mesoderm development
transcription coactivator binding
notochord development
hippo signaling
disordered domain specific binding
RNA polymerase II transcription factor binding
embryonic heart tube morphogenesis
vasculogenesis
cellular response to retinoic acid
embryonic heart tube development
neural tube closure
tube closure
primary neural tube formation
neural tube formation
response to retinoic acid
regulation of stem cell differentiation
embryonic epithelial tube formation
mesoderm development
epithelial tube formation
morphogenesis of embryonic epithelium
tube formation
neural tube development
transcription initiation from RNA polymerase II promoter
transcription factor complex
cellular response to acid chemical
DNA-templated transcription, initiation
transcription regulatory region DNA binding
mesenchyme development
heart morphogenesis
embryonic organ morphogenesis
epithelial tube morphogenesis
response to acid chemical
blood vessel morphogenesis
sequence-specific DNA binding
morphogenesis of an epithelium
embryonic organ development
transcription by RNA polymerase II