THNSL2

Entrez Summary: This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
UniProt Summary: Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Lapatinib 5μM R01 exp47	1.7
Cidofovir 10μM R07 exp345	1.78

threonine biosynthetic process
2-oxobutyrate biosynthetic process
threonine synthase activity
2-oxobutyrate metabolic process
short-chain fatty acid biosynthetic process
serine binding
threonine metabolic process
serine family amino acid catabolic process
short-chain fatty acid metabolic process
aspartate family amino acid biosynthetic process
serine family amino acid metabolic process
aspartate family amino acid metabolic process
pyridoxal phosphate binding
alpha-amino acid biosynthetic process
cellular amino acid biosynthetic process
alpha-amino acid catabolic process
fatty acid biosynthetic process
cellular amino acid catabolic process
cytokine activity
monocarboxylic acid biosynthetic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
dephosphorylation
cellular amino acid metabolic process
fatty acid metabolic process
small molecule catabolic process
cellular component
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
molecular function
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
lipid metabolic process