THRAP3

Gene Information

Official Symbol: THRAP3
Official Name: thyroid hormone receptor associated protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 9967
UniProt: Q9Y2W1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Lead acetate 2000μM R08 exp498 no dilution day6	-1.9
Rapamycin 1μM R00 exp29	1.73
Rifampicin 1μM R00 exp31	1.74
Deguelin 0.15μM R05 exp209	1.82
YM155 0.0002μM R01 exp61	1.96
Latrunculin-B 10μM R07 exp374	2
Doxorubicin 0.02μM R08 exp478	2.01
Nutlin-3A 1.6μM R06 exp294	2.01
CB-5083 0.4μM R08 exp468	2.87
Tozasertib 0.1μM R07 exp414	3.42

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1178
Expression level (log2 read counts): 8.7

Expression Distribution

vitamin D receptor binding
positive regulation of circadian rhythm
exon-exon junction complex
positive regulation of mRNA splicing, via spliceosome
thyroid hormone receptor binding
positive regulation of mRNA processing
positive regulation of RNA splicing
phosphoprotein binding
mediator complex
mRNA stabilization
RNA stabilization
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
regulation of alternative mRNA splicing, via spliceosome
nuclear receptor transcription coactivator activity
positive regulation of mRNA metabolic process
negative regulation of mRNA metabolic process
transcription coregulator activity
RNA polymerase II distal enhancer sequence-specific DNA binding
regulation of mRNA splicing, via spliceosome
regulation of circadian rhythm
regulation of RNA splicing
regulation of mRNA processing
circadian rhythm
transcription initiation from RNA polymerase II promoter
regulation of mRNA stability
regulation of RNA stability
nuclear-transcribed mRNA catabolic process
regulation of mRNA catabolic process
DNA-templated transcription, initiation
mRNA catabolic process
RNA catabolic process
negative regulation of cellular catabolic process
rhythmic process
transcription coactivator activity
negative regulation of catabolic process
regulation of mRNA metabolic process
nucleobase-containing compound catabolic process
RNA splicing
nuclear speck