TLDC1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Adefovir 20μM R07 exp332	-1.78
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.75
Nutlin-3A 1.6μM R06 exp294	1.85

positive regulation of protein localization to lysosome
regulation of protein localization to lysosome
negative regulation of oxidative stress-induced neuron death
regulation of oxidative stress-induced neuron death
TOR signaling
negative regulation of cellular response to oxidative stress
negative regulation of oxidative stress-induced cell death
negative regulation of response to oxidative stress
regulation of oxidative stress-induced cell death
regulation of cellular response to oxidative stress
regulation of response to oxidative stress
response to amino acid
negative regulation of neuron death
response to insulin
lysosomal membrane
regulation of neuron death
positive regulation of cellular protein localization
response to acid chemical
response to peptide hormone
response to peptide
response to nutrient levels
response to extracellular stimulus
regulation of cellular protein localization
regulation of cellular response to stress
regulation of cell migration
response to hormone
regulation of cell motility
regulation of cellular localization
regulation of locomotion
negative regulation of cell death
regulation of cellular component movement
response to organonitrogen compound
regulation of protein localization
response to nitrogen compound
response to endogenous stimulus
regulation of response to stress
response to oxygen-containing compound
regulation of cell population proliferation
negative regulation of response to stimulus
regulation of cell death