TLR5

Gene Information

Official Symbol: TLR5
Official Name: toll like receptor 5
Aliases and Previous Symbols: N/A
Entrez ID: 7100
UniProt: O60602
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16300
Expression level (log2 read counts): -0.64

Expression Distribution

LRR 4
TIR

toll-like receptor 5 signaling pathway
interleukin-1 receptor binding
positive regulation of toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
positive regulation of interleukin-8 production
regulation of toll-like receptor signaling pathway
regulation of interleukin-8 production
cellular response to mechanical stimulus
toll-like receptor signaling pathway
pattern recognition receptor signaling pathway
transmembrane signaling receptor activity
regulation of cytokine secretion
response to mechanical stimulus
innate immune response-activating signal transduction
activation of innate immune response
cellular response to environmental stimulus
cellular response to abiotic stimulus
defense response to bacterium
cellular response to external stimulus
positive regulation of innate immune response
positive regulation of response to biotic stimulus
positive regulation of cytokine production
regulation of innate immune response
regulation of protein secretion
positive regulation of defense response
regulation of peptide secretion
inflammatory response
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
response to bacterium
regulation of cytokine production
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of defense response