TMBIM6
Gene Information
- Official Symbol: TMBIM6
- Official Name: transmembrane BAX inhibitor motif containing 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 7009
- UniProt: P55061
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity). {ECO:0000250|UniProtKB:Q9D2C7, ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}.
Pfam Domains GO Terms
Pfam Domains
| Bax1-I |
GO Terms
| negative regulation of endoribonuclease activity |
| endoribonuclease inhibitor activity |
| negative regulation of ribonuclease activity |
| negative regulation of immunoglobulin secretion |
| negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
| regulation of endoribonuclease activity |
| regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| negative regulation of cellular response to hypoxia |
| negative regulation of nuclease activity |
| regulation of ribonuclease activity |
| response to L-glutamate |
| negative regulation of immunoglobulin production |
| negative regulation of transcription from RNA polymerase II promoter in response to stress |
| regulation of cellular response to hypoxia |
| negative regulation of calcium ion transport into cytosol |
| regulation of immunoglobulin secretion |
| negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| regulation of nuclease activity |
| endoplasmic reticulum calcium ion homeostasis |
| negative regulation of RNA splicing |
| regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| negative regulation of production of molecular mediator of immune response |
| negative regulation of response to endoplasmic reticulum stress |
| negative regulation of calcium ion transport |
| regulation of immunoglobulin production |
| regulation of response to endoplasmic reticulum stress |
| negative regulation of intrinsic apoptotic signaling pathway |
| regulation of calcium ion transport into cytosol |
| mitochondrial membrane |
| negative regulation of protein binding |
| response to amino acid |
| regulation of transcription from RNA polymerase II promoter in response to stress |
| negative regulation of immune effector process |
| regulation of DNA-templated transcription in response to stress |
| cellular response to unfolded protein |
| negative regulation of protein secretion |
| regulation of RNA splicing |
| negative regulation of peptide secretion |
| regulation of production of molecular mediator of immune response |
| negative regulation of ion transport |
| cellular response to topologically incorrect protein |
| intrinsic apoptotic signaling pathway |
| regulation of intrinsic apoptotic signaling pathway |
| response to unfolded protein |
| negative regulation of binding |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| response to topologically incorrect protein |
| negative regulation of secretion by cell |
| response to nutrient |
| regulation of protein binding |
| negative regulation of apoptotic signaling pathway |
| negative regulation of secretion |
| regulation of calcium ion transport |
| response to endoplasmic reticulum stress |
| process utilizing autophagic mechanism |
| autophagy |
| apoptotic signaling pathway |
| ubiquitin protein ligase binding |
| response to acid chemical |
| enzyme binding |
| regulation of binding |
| regulation of metal ion transport |
| regulation of apoptotic signaling pathway |
| cellular calcium ion homeostasis |
| negative regulation of immune system process |
| calcium ion homeostasis |
| negative regulation of hydrolase activity |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| regulation of immune effector process |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| response to nutrient levels |
| negative regulation of intracellular signal transduction |
| response to extracellular stimulus |
| cellular metal ion homeostasis |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of ion transport |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of secretion |
| negative regulation of transcription by RNA polymerase II |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cellular localization |
| apoptotic process |
| endoplasmic reticulum membrane |
| negative regulation of cell death |
| response to organonitrogen compound |
| endoplasmic reticulum |
| response to drug |
| regulation of protein localization |
| programmed cell death |
| response to nitrogen compound |
| cell death |
| chemical homeostasis |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| integral component of plasma membrane |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| cellular catabolic process |
| regulation of intracellular signal transduction |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CHIR-124 0.04μM R06 exp272 | 1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14751
- Expression level (log2 read counts): 8.51
Expression Distribution
TMBIM6 Expression in NALM6 Cells: 8.51
